2023 SignalHire.com is operated by SENDERSYSTEMS LIMITED, AllianThera Biopharma headquarters is in Suzhou, Jiangsu. view more Credit: Insilico Medicine. Dr. Cote-Sierra, an immunologist with strong drug discovery and early clinical development expertise acquired through his years at Millennium Pharmaceuticals (Takeda now), Roche and GSK, was recently the Head of Inflammation and Immunology External Innovation at Sanofi Partnering where he and his team contributed to multi-program collaborations and acquisitions. "Dr. Ding is one of the most respected biopharmaceutical executives in our industry focusing on novel drugs and technologies and we had the pleasure of working with him. The company reckons it can succeed where other cell therapies have failed, but proof is a long way off. The company researches biological target by leveraging artificial intelligence technologies, committing to discovering efficient G Protein-Coupled Receptors (GPCR) targeted drug. Suzhou-based AllianThera emerged from stealth this week with a discovery and development deal with AI play Insilico, undisclosed seed funding and a leadership team hailing from big pharma. Copyright 2017-2022 Alpha Biopharma Ltd. All rights reserved. We take on biologically-validated targets that have been previously elusive but that have the potential to transform medicine. Would you like email updates of new search results? GSK shows that Cabenuva every two months is as good as daily Biktarvy, but Gilead looks to go even longer. Terms were not disclosed. Using a physiologic antigen recognition model, inactivation of CD73 significantly increased antigen-specific CD8+ T-cell immunogenicity following PEM treatment. Website http://insilico.com/. 328 Xinghu Street, Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone. Linkedin. A readout in the next few weeks could put pemvidutide on course for blockbuster sales or not. AllianThera Biopharma comes out of stealth and collaborates on AI with Insilico Medicine. PMID: 36066413 DOI: 10.1158/0008-5472.CAN-22-0770 Abstract Immunotherapy has shown limited efficacy in EGFR-mutated lung cancer patients. The companies utilized a pipeline of Insilico Medicine's artificial intelligence platforms including PandaOmics to identify a list of promising targets in cancer and autoimmune diseases and prioritize novel high-confidence targets to progress into early-stage drug discovery. Claim your Free Employer Profile. By using this site, you agree that we may store and access cookies on your device. Company. If uncontrolled, diabetes could result in life threatening conditions like ketoacidosis, and chronic . AllianThera Biopharma Overview Work Here? Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI-Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation. Thursday, 25th of March 2021 (5:00AM EST) -- Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of. AllianThera Biopharma is Drug Discovery in China that focus on Protein-Coupled Receptors business. Altimmune aims to build Momentum in obesity, Go or no go? China, developerGPCR-target drugbiological targetartificial intelligence technology(GPCR. Close Appointment form contact@ai-biopharma.com Categories Home Company Services Pipeline News & Events Contact However, PEM treatment also induced adenosine production, which inhibited T-cell responsiveness. Please visit the vantage homepage for our latest articles or search our articles via the buttons below. ATB is a newly established biotechnology company led by seasoned drug hunters, Dr. Yuan-Hua Ding (CEO) and Dr. Javier Cote-Sierra (CSO), with seed money from Bohe Angel Fund, Anlong Venture andKatai Capital. Jobs at AllianThera Biopharma. The cytosolic DNA-sensing cGAS-STING pathway in cancer. Vaccines and neurology up for discussion, CROI 2023 GSK and Gileads long-acting HIV battle intensifies, CROI 2023 progress on efforts to cure HIV, Spotlight Cystic fibrosis developers take a deep breath, US deal watchdog's bark could be worse than its bite, Novo sows the seeds for a new heart failure approach. Business Type Drug Discovery Country China Founded 2020 ( 3 years old in 2023 ) Company Focus Dr. Ding and Dr. Cote-Sierra together with Prof. Zhijie Liu, a well-known GPCR structural biologist at the ShanghaiTech University, co-founded ATB to combine deep disease biology and drug R&D know-how with breakthrough technologies to tackle difficult diseases with underline disorders in the immune system. Terms and Conditions I agree to the terms of the Usage AgreementI agree to the terms of the Privacy Policy Create My Account Site Map Terms of Use Privacy Policy 9 Guanghua Road, Chaoyang District, Beijing. Our Pharma.AI platform has the potential to rapidly bring novel breakthrough medicines to patients . Founded in 2020. GT Biopharma, Inc. is a clinical stage biopharmaceutical company focused on the development and commercialization of immuno-oncology therapeutic products based our proprietary TriKE NK cell . A, PEM treatment co-opts cGAS-STING signaling, PEM treatment co-opts cGAS-STING signaling in MET-amplified EGFR-TKIresistant cells. AllianThera Biopharma headquarter office and corporate office address is located in 4-B101-125, Creative Industry Park, No. A, TCR expression, CD73 coactivation with STING in MET-driven EGFR-TKIresistant cells. Independent, data-driven daily news and analysis on pharma, biotech and medtech. The latest edition of the PD(L)anner focuses on combinations, and analyses the difficulties China developers are having with US approvals. 328 Xinghu Street -, DaSilva JO, Yang K, Surriga O, Nittoli T, Kunz A, Franklin MC, et al. Since its inception, Insilico Medicine raised over $52 million, published over 100 peer-reviewed papers, applied for over 25 patents, and received multiple industry awards. Reports the latest medical biotech, pharma, clinical trials, FDA, mergers, acquisitions, funding and more. 13 Dana-Farber Cancer Institute, Boston, Massachusetts, United States. SUZHOU, China, March 25, 2021 /PRNewswire/ -- Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and . Shi P, Oh YT, Zhang G, Yao W, Yue P, Li Y, Kanteti R, Riehm J, Salgia R, Owonikoko TK, Ramalingam SS, Chen M, Sun SY. Bookshelf Founder, CEO & Director Co-Founder and CEO of Izana Bioscience & Akaza, Co-Founder of Pathios Therapeutics, Co-investor, Former MD in ECM at Socit Gnrale and ABN AMRO Rothschild, Founder of Cryfield Investments, Co-Founder of MoonLake Immunotherapeutics and Former Head of Global Business Unit Immunology, Hepatalogy and Dermatology at Novartis, Co-Founder & CSO of Allianthera Biopharma and Former Head of Inflammation & Immunology External Innovation at Sanofi Genzyme, Co-Founder & CEO of Allianthera Biopharma and Co-CEO at the BayRay Innovation Center, former Head of Pfizer Asia Discovery Labs, JATT Acquisition Corp. is made up of a team of global drug hunters, proven entrepreneurs, pharma veterans and financial operators. All content is posted anonymously by employees working at AllianThera Biopharma. work@designtx.com. General. Primary Office 4-B101-125, Creative Industry Park, No. A, Tumor volume of HCC827GR6 cells with, MeSH A, H69/H69M HGF-derived, CD73 generates adenosine in MET-amplified, CD73 generates adenosine in MET-amplified EGFR-TKIresistant cells and is regulated by FRA1. FOIA view more. . With several decades of combined experience and successful multi-billion dollar deals, we have honed our formula to unlock future value powered by deep sector and capital markets knowledge, Closing of 138 Million Initial Public Offering, Ordinary Shares and Warrants will Commence Separate Trading. 2019 Oct;21(10):1287-1301. doi: 10.1007/s12094-019-02075-1. AllianThera Biopharma 5 jobs. In 2023, AllianThera Biopharma is currently focus on Protein-Coupled Receptors sector. Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of diseases, and Insilico Medicine, a global leader in deep learning for drug discovery and development, announced a collaboration to discover and develop molecules for novel targets in cancer and 6005 Hidden Valley Road Suite 110 Carlsbad, CA 92011 858-293-4900. Industry Presence Many of the world's largest companies are operating and investing in our communities. This website expressly disclaims the accuracy, adequacy, or completeness of any data and shall not be liable for any errors, omissions or other defects in, delays or interruptions in such data, or for any actions taken in reliance thereon. These data reveal that combined PEM and CD73 inhibition can co-opt tumor cell STING induction in TKI-resistant EGFR-mutated lung cancers and promote immunogenicity. ATB is funded by Anlong Venture, Bohe Angel Fund and Katai Capital. We also use them to share usage information with our partners. See this image and copyright information in PMC. Systematic genomic analyses and cell line studies confirmed upregulation of CD73 in MET-amplified and MET-activated lung cancer contexts, which depends on coinduction of FOSL1. Recently, Insilico Medicine secured $37 million in series B funding. See All News. Description. Copyright 20082023, Glassdoor, Inc. "Glassdoor" and logo are registered trademarks of Glassdoor, Inc. Find a Great First Job to Jumpstart Your Career, Learn How to State Your Case and Earn Your Raise, Work Here? Using aging as a way to identify disease, he says, Insilico has trained AI to do what it does best take large amounts of data from many components to identify new targets, and new molecules. Alpha Biopharma - Specialize in drug innovation from clinical development to commercialization success. CD73 generates adenosine in MET-amplified EGFR-TKIresistant cells and is regulated by FRA1. Show more AllianThera Biopharma headquarters is in Suzhou, Jiangsu. With CMV in its sights, the Oxford University spinout is poised to take its novel VLP vaccine technology into the clinic. and transmitted securely. SUZHOU, China, March 25, 2021 /PRNewswire/ -- AllianThera Biopharma comes out of stealth and collaborates on AI with Insilico Medicine are not responsible for the accuracy of news releases posted to EurekAlert! Dr. Ding and Dr. Cote-Sierra, each has 20+ years of R&D experiences and leadership roles in major pharmas, were former colleagues at Pfizer. Epub 2016 Sep 9. AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune . We use cookies on this website. . To connect with AllianThera Biopharma's employee register on Signalhire, Get the email address format for anyone with our FREE extension. The site is secure. They cover business area such as developer, GPCR-target drug, biological target, artificial intelligence technology, (GPCR. Alpha Biopharma Specialize in drug innovation from clinical development to commercialization success. Developer of GPCR-targeted drug. Allianthera Boston, Inc. is a Massachusetts Domestic Profit Corporation filed on March 25, 2021. It's caused by lack of insulin or insufficient insulin responses, leading to abnormal metabolism of sugar, protein and fat with imbalance of water and electrolytes. We are very happy that he decided to form a company focused on leading-edge technologies with transformative potential, assembled a great team of seasoned drug hunters and chose to collaborate with us, on both target discovery and generative chemistry," said Alex Zhavoronkov, PhD, CEO of Insilico Medicine. Bethesda, MD 20894, Web Policies Stanford professor Michael Levitt, PhD, a member of Insilico Medicine's Scientific Advisory Board, won the Nobel Prize in Chemistry in 2013 for his groundbreaking work in protein structure and protein folding using computer modeling. Reach out to AllianThera Biopharma directly regarding career opportunities. AllianThera Biopharma is in the sectors of: Pharma. Cancer Lett. Clin Transl Oncol. Sorry, we didn't find any related vantage articles. However, STING activation was restrained by ectonucleosidase CD73, which is induced in MET-amplified, EGFR-TKI-resistant cells. FDA panels loom for GSK and Biogen, with approval decisions due for Acadia and Biomarin. Since 2014 Insilico Medicine is focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trials outcomes. 700, Boston, MA 02110. Polly Firs Design Therapeutics. polly.firs@insilico.com, Copyright 2023 by the American Association for the Advancement of Science (AAAS), /Life sciences/Biochemistry/Pharmacology/Drug development/, /Health and medicine/Clinical medicine/Medical treatments/Cancer treatments/, /Health and medicine/Medical specialties/Immunology/Immune disorders/. , you agree that we may store and access cookies on your device physiologic antigen recognition model, inactivation CD73. Target by leveraging artificial intelligence technology ( GPCR ) targeted drug recently, Medicine... 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And access cookies on your device cell therapies have failed, but proof is a long way off lung patients. Daily news and analysis on pharma, clinical trials, FDA,,... To Combination Met-TKI/EGFR-TKI Exposure in MET-amplified EGFR-TKI-Resistant lung Adenocarcinoma Harboring an Activating EGFR Mutation AllianThera Biopharma 's employee on. 13 Dana-Farber cancer Institute, Boston, Massachusetts, United States take on biologically-validated targets that the... Treatment co-opts cGAS-STING signaling in MET-amplified EGFR-TKI-Resistant lung Adenocarcinoma Harboring an Activating EGFR Mutation format for with! Pilot Free Trade Zone result in life threatening conditions like ketoacidosis, and chronic operating and investing in our.... Is drug Discovery in China that focus on Protein-Coupled Receptors ( GPCR technology, ( GPCR of search... Exposure in MET-amplified EGFR-TKIresistant cells by using this site, you agree that may... 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