All three ingredients have their own special task which they handle to perfection. Keep this and all drugs out of reach of children. On Aug. 14, while sitting in the backyard enjoying our day off, I stood up from my chair and had . This will often reveal flea excrement and fast-moving fleas. Dosage is at 0.91mg/lb (2mg/kg) Simparica should only be administered to dogs 6 months of age and older. Some of the worst parasites that can infect your dogs are; It can be confusing remembering what medication your dog should take and when. You can give it to your dog once a week, but it is best to give your pet Simparica every month, because its a monthly treatment. Simparica Chewables for Dogs above 88 lbs (Red) 3 Pack is of $39.79 6 Pack is of $68.42. As of Jul. In a 10-day multi-center field study, SIMPARICA TRIO was effective against Toxocara canis and reduced fecal egg counts 99.2%. What are the side effects of cefpodoxime for dogs? In fact, the production company performed a safety study that included a total of 808 dogs with different issues. In safety studies with tested puppies from 6 weeks of age. Seizures in dogs . What are the side effects of proin for dogs? Cons. It is not advisable for humans to shampoo a pet with Simparica Trio. On the other hand, Moxidectin helps in proper heartworm prevention. No adverse effects were observed at the maximum exposure dose of 4 mg/kg. He gave me a free sample of Simparica and told me to give her one that afternoon. It was proven to be effective in eradicating immature stages of Toxocara canis in dogs, and resulted in a 91.7% reduction in the count of fecal eggs. What are the side effects of rimadyl for dogs? Precautions. Bigger one will need more 5 tablets even reach up to 100. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. With the abundance of parasiticides available today which protect our dogs from ectoparasites, its vital for us to examine how safe and effective these products are. In isolated cases, however, dogs displayed . Simparica is a monthly chewable that . PARSIPPANY, N.J - July 27, 2022 - Zoetis is aware of a social media post originating on Facebook that references Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets,), a potential neurologic adverse event and the subsequent euthanasia of a dog in the U.S. Sarolaner is also used in combination products for both dogs and cats. Sarolaner tablets were also highly palatable with 90.5% acceptance by free choice within one minute of offering., Sarolaner administered orally twice at monthly intervals at the minimum label dosage of 2 mg/kg was safe and achieved complete parasitological cure in dogs with natural infestations of Sarcoptes Scabiei. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick remedy and already several dogs have been adversely affected by this new drug. January 27, 2023. When you give your dog the monthly chewable medicine Simparica, you give it extra protection from fleas and ticks. Pyrantel Pamoate was first approved in 1977 for the treatment and . Some dogs also experience a temporary loss of appetite and may not eat their food at their usual meal times. Safe for dogs and puppies 2 pounds of body weight or greater and 4 weeks of age and older. Small dog will take at least 5 tablet. What are the side effects of Simparica trio for dogs? If you purchase something through our links, we may earn a referral fee. Moxidectin acts by interfering with the chloride channel.mediated neurotransmission in the parasite. Usually most diarrhea will run its course within two to four days, although in some cases, it can last longer. He had been taking the it for about 2-3 months. Consult with your veterinarian as to the correct dosing schedule. Nexgard (active ingredient afoxolaner) and Bravecto (fluralaner) were approved in the US in late 2013 and early 2014. . The first step of getting the Simparica Trio protection or treatment for your dog is visiting your vet. However, its important to understand that SIMPARICA TRIO is for dogs only and is not for humans. The FDA regulated this drug, and it can only be prescribed by a licensed vet. Safe for puppies seven weeks and older. It results in severe pruritus, and can lead to secondary bacterial pyoderma. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. Simparica Trio must only be used when there is a need to treat both fleas or ticks and worms in the gut. Both Nexgard and Simparica are effective in preventing flea infestations, but there are some disadvantages associated with both products. It is given once a month. Never double up on doses. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. The medication is not toxic to the dog, and many dogs experience only a slight stomach upset following treatment. The drug has a very low side effect rate compared to the two sister drugs. Credelio kills fleas, the Lone Star tick, American dog tick, black-legged tick, and brown dog tick. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Slow-dissolving microspheres contain and prolong the effects of moxidectin-which redistributes from plasma to adipose tissue. Simparica Chewables for Dogs 44.1-88 lbs (Green) 3 Pack is of $38.07 6 Pack is of $62.36. Dogs in the control group received placebo. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is concerning. Simparica is administered once a month as a flavored chewable. Can you give NexGard and Heartgard together? Simparica Trio is a chewable tablet that contains three proven ingredients. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Although Simparica Trio is considered safe by the FDA and is one of the few isoxazoline-based parasite prevention products available for dogs, some pet owners prefer a separate product. After being ingested by a dog, sarolaner is distributed throughout the body. The most common Simparica Trio for dogs side effects are; Hyperactivity, polydipsia, and polyuria happened in very rare cases. Her bowels and blood test came out fine. Also read our comparison of the two products! What are the side effects of cytopoint for dogs? Simparica Trio. This results in paralysis and death of the parasite. span I comment. When given correctly, Simparica kills fleas within three hours. No adverse reactions were associated with the concurrent use of SIMPARICA TRIO and other medications. If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing. My articles have appeared in a variety of magazines including Pets Magazine, Action Dog and Puppy Love. What are the side effects of dasuquin for dogs? Is a third Isoxazoline drug really necessary while the two older ones have not even been proven beyond doubt to be safe for our furkids? It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. Keep SIMPARICA TRIO in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose. Simparica (sarolaner) tablets for dogs Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats Sarolaner is a member of the isoxazoline class of parasiticides and the chemical name is 1-(5-((5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-3-H-spiro(azetidine-3,1-(2) benzofuran)-1-yl)-2-(methylsulfonyl)ethanone. Repeat the process once every month for effective control. Controversial tick and flea "remedies" Nexgard and Bravecto were both approved and released in late 2013 and early 2014 respectively. Save my name, email, and website in this browser for the next time I comment. Simparica is more effective against ticks, but there are side effects. Following intravenous (IV) dosing of a combination solution of sarolaner and moxidectin, the sarolaner volume of distribution (Vss) was 2.4 L/kg and systemic clearance (CL) was 6.0mL/kg/hr. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae. Only two of 11 (18%) placebo-treated dogs that did not receive any immuno-suppression harbored live mites on day 60. Zoetis (Simparica): 888-963-8471; To report directly to the FDA, or for more information on adverse drug experience reporting for animal drugs, visit the FDA's article on "How to Report Animal Drug Side Effects and Product Problems." Source: Pexels the FDA is continuing to monitor reports related to these flea and tick medications. More importantly, it controls ticks such as the Lone Star tick, Gulf Coast tick, American Dog tick, black-legged tick, and the brown dog tick. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. I really miss having her with me. Simparica works rapidly due to its active ingredient, sarolaner, which is a systemic insecticide that is fast-acting and kills fleas within three hours after the administration of a flavored Simparica chewable. Elimination of roundworms (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) was demonstrated in well-controlled laboratory studies. I gave it to her at 4 and by 6 she had diarrhea. For this reason, its essential to bring your dog to the veterinarian for a full check-up. Simparica Trio kills 5 species of ticks such as gulf coast ticks, American dog ticks, Lone star ticks, deer ticks, and Brown dog ticks. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. it helps to prevent ear mites, flea allergy dermatitis, tick bite fever, and anemia resulting from tick bite fever. As of late, there are not many publications as to the toxicity of Sarolaner on the environment, or on pets. Simparica trio is a de-worming medication. Against Amblyomma americanum, SIMPARICA TRIO demonstrated 99.4% effectiveness 72 hours after treatment of existing infestations, and maintained 98.4% effectiveness 72 hours after re.infestation for at least 28days. Pet owners and veterinarians who have additional questions can contact AskCVM@fda.hhs.gov or call 240-402-7002. We had to put our sweet, sweet Cuddles to sleep a week ago. This medication offers protection for 35 days. It protects your dog against heartworm disease, fleas, roundworms, and hookworms. 2 0. However, there are some crucial questions dog owners want to know the answer to. if(typeof ez_ad_units!='undefined'){ez_ad_units.push([[320,100],'worlddogfinder_com-medrectangle-3','ezslot_15',138,'0','0'])};__ez_fad_position('div-gpt-ad-worlddogfinder_com-medrectangle-3-0'); The most important question about any chewable tablet is, Is it safe for my dog? Protection against parasites is essential, but if risks outweigh the benefits, it might be worth looking into other types of protection. Moxidectin is a pentacyclic 16-membered lactone macrolide. SIMPARICA TRIO should be administered year-round at monthly intervals or started at least one month before fleas become active. He was euthanized after suffering for a month of seizures. The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); How Long Can a Greyhound Run at Top Speed? Dogs with neurological conditions should also be monitored closely for signs of side effects such as tremors and seizures. He didn't think it was from the pill. on 2022-06-28 by Kathy Auten Flag. What are the side effects of steroids in dogs? Luckily, Simparica Trio for dogs is considered fairly safe. In studies it started killing within four hours, and achieved 100% effectiveness in eight hours. Your dog can still contract a tick borne disease because the drugs dont even repel the parasites. NexGard is appropriate for dogs over six months of age, while Simparica is appropriate for puppies from two to four pounds. The percentages of dogs with live mites in the placebo group on days 14, 30, 44 and 60 were 52.4, 35.0%, 36.8 and 38.9%, respectively. What are the side effects of chemo in dogs? If you prefer online orders, you can order it on Chewys online pharmacy. Simparica Trio does require a prescription. On Aug. 10, I gave Zeke his monthly dose of Simparica (80 mg flea and tick treatment, chewable). Not for use in humans. In a well-controlled laboratory study, SIMPARICA TRIO began to kill existing I. scapularis within 8 hours, SIMPARICA TRIO reduced the number of live ticks by 94.2% within 24 hours of infestation for 28 days. Credelio. The most frequent reactions reported in the SIMPARICA TRIO group are presented in the following table. How long does flea medicine toxicity last? She was bleeding to death internally, vomiting, tremors, unsteady, would fall when she would try to walk, salivating. They have to bite and attach to the dog and take a toxic blood meal off the victim in order to die. Simparica Trio is a chewable tablet for dogs. The below directions will help you to use the product correctly. Simparica Trio costs $135 to $150 depending on your dog's weight. Sarolaner has fast and consistent efficacy for the full dosing period against fleas and multiple species of ticks. Are there any side effects of NexGard or NexGard SPECTRA? When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. It broke my heart to see the pain I put her through by giving her Simparica. They are blood-sucking parasites that attach themselves to humans and animals. It is FDA-approved for heartworm prevention and is safe to give to puppies as young as eight weeks old and weighing 2.8 pounds. Bernadette Dunham, D.V.M., Ph.D., Director, Center for Veterinary Medicine at the FDA, This site is protected by reCAPTCHA and the Google. Based on official information, simparica is for treatment related to the flea and tick. After reading the story of Cuddles as posted directly from Susan Rae'sFacebook profile, as well as the attached ADE report and the two articles on the safety of the Isoxazoline drugs, please decide for yourself. Ticks carry deadly diseases, so you will have the peace of mind in knowing that if a tick does get on your dog, it is going to die. . This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. SIMPARICA TRIO contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. While she was still alive, after the drug was administered: I spent the entire day at the Emergency Veterinary Clinic. This is an essential attribute of effective ectoparasiticides in that Sarolaner improves primary parasite control, and reduces the potential for pathogen transmission. In addition to being inexpensive, Simparica Trio is easy to administer because it only needs to be given once a month. There are no known side . In the last few years, oral treatments have become immensely popular compared Read More, According to a community of vets, the result of using this product on many dogs has Read More, Best Flea, Tick & Heartworm Prevention for your Dog. Flea allergy dermatitis tends to occur mostly in the late summer. Its an affordable, effective remedy for many parasitic infections and infestations. Intestinal Nematode Treatment and Control: For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections, SIMPARICA TRIO should be administered once as a single dose. A single oral dose of Simparica Trio was safe and highly efficacious against naturally occurring flea and tick infestations for 1 month on dogs. Distributed by: Zoetis Inc., Kalamazoo, MI 49007. Both dogs recovered without treatment. Side effects with Simparica are not common. Adverse reactions are rare, and most dogs take Simparica without any problems. It can be given to dogs all year round at monthly intervals and is safe for every dog in the household. We comply with the HONcode standard for trustworthy health information. My Baby has liver disease and acute pancreatitis. Her kidneys and liver had even improved, but she did have fleas. Through research I have found that Simparica, Bravecto, and Nexguard all have one thing in common, they kill dogs! How much does a pack of simparica cost? Added: 2023-01-23 I am so sad and depressed. There were no clinically.relevant, treatment related effects on clinical observations, body weights, food consumption, clinical pathology (hematology, coagulation, serum chemistry, and urinalysis), gross pathology, histopathology, or organ weights. A clinic stay for your dog will most likely be recommended by your veterinarian. If we can choose, we would take a simple medication that provides all-around protection. Cuddles is with me 24/7 since I am currently homebound. Instead, it kills larvae, allowing your dog to avoid infection. Available for dogs of almost any size. Simparica. Interceptor Plus has a 96.6% overall acceptability. In contrast, one of three dogs (33%) that were started on immuno-suppression before day 30, and all four dogs (100%) that were immuno-suppressed for the entire study had live mites on day 60.. however, the following side effects are seen in less than 1 dog in 10, 000: mild and short-lived vomiting and diarrhoea as well as tremor (shaking), ataxia (inability to coordinate body movements) or convulsions. In a well-controlled 60-day US field study conducted in dogs with existing flea infestations of varying severity, the effectiveness of SIMPARICA TRIO against fleas on Day 30 and 60visits was 99.0% and 99.7%, respectively, compared to baseline. However, they are possible, so it is better to know they might happen. That means most dogs will take their dose. The medication is supposed to control the parasites that cause these seizures, including roundworms, hookworms, and fleas. So, heres some good news for dog parents. The abnormal movement can occur in the legs, the head, the torso, or all three. Your email address will not be published. The safety studies for NexGard had a good outcome . Some types of ticks may favor attaching and feeding around the head, neck and shoulder area, while other species of ticks will prefer the ear, anus, and beneath the tail area. Moxidectin is an endectocide in the macrocyclic lactone class. Simparica Side effects. Eggs, larvae, and flea excrement will most likely also be found on the dogs bedding. Adverse reactions in dogs treated with SIMPARICA TRIO included diarrhea and vomiting. Decreased conscious proprioception. Select one or more newsletters to continue. But, even though it is still relatively new on the market, side effects associated with Simparica are rare. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). What are the side effects of simparica trio for dogs? What are the side effects of adequan for dogs? . Then the tremors started. Adverse reactions are rare, and most dogs take Simparica without any problems. I have been crying all day. After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. Does not require a prescription. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. Is there a generic version of Simparica Trio? SIMPARICA can be offered by hand, in the food, or administered like other tablet medications. Content on this site is intended for informational purposes only and does not constitute professional, medical or healthcare advice or diagnosis, and may not be used as such. The best way to answer this question is by consulting your veterinarian. Abnormal neurological effects were observed at dosages between 12 to 24 mg/kg, 3 to 5 . SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). See the Terms of Use for further details. Your pets problem could be solved with the simple administration of a yummy tasting tablet. How long do side effects last from Simparica trio? Cuddles had NEVER had fleas in her life. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. The adipose tissue acts as a reservoir, allowing efficacy. The most common Simparica Trio for dogs side effects are; Lethargy . SIMPARICA TRIO was administered orally once at 1, 3 and 5X the maximum labeled dose to Collies that had been pre.screened for avermectin sensitivity. Fortunately, side effects are rare, and if they do occur, they do not last long. A 10-year-old boxer named Blayz was given the anti-parasitic drug Simparica TRIO to treat a recurring case of heartworm in his dog. Revised: November 2020. This combination of three medicines provides fast results for prevention and treatment of parasitic problems. Following oral administration of SIMPARICA TRIO in Beagle dogs (13 to 15 months of age at the time of initial dosing), sarolaner and moxidectin were rapidly and well-absorbed. If it ended there, and thequality of our pets' liveswere improved by these so-called remedies, theywould have been welcomed with open arms but it doesn't end with killing the pests; numerous side effects have been experienced bymanybeloved pets and reported by their owners, including severe gastritis, vomiting, bloody diarrhea, seizures and even several deaths. What are the side effects of denamarin for dogs? It works at the neuromuscular site in insects, leading to the elimination of insects or acarines. Two dogs were removed from the sarolaner group when they were identified as being pregnant during the study.. Which is safer: Nexgard or Simparica? Your veterinarian can tell you which product is right for your dog and what to avoid. It remains 100 percent effective against adult fleas and weelies for 35 days. Dogs younger than one year of age usually do not have flea allergy dermatitis. At a moxidectin dose of 0.024 mg/kg, the moxidectin mean Cmax was 13.1 ng/mL with a mean Tmax of 2.4 hours and an absolute bioavailability of 67%. Luckily, dogs treated with Simparica had mild side effects that were gone 24 hours after the initial administration. Total waste of time. Would lean against the wall and hang her head down. Through research I have found that Simparica, Bravecto, and Nexguard all have one thing in common, they kill dogs! Some of its competitors only offer protection against 4. To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2.8-5.5 pounds. Following a single oral dose of SIMPARICA TRIO (sarolaner dose of 1.2mg/kg), the sarolaner mean maximum plasma concentration (Cmax) was 523 ng/mL with a mean time to maximum concentration (Tmax) of 3.5 hours and an absolute bioavailability of 88%. Protects against 5 types of ticks, roundworms, and hookworms, Waterproof (shampooing once a week can reduce effectiveness), Removes and controls whipworms in dogs and puppies. This particular product is the advanced version of the currently existing Simparica chewables and is believed to become the number one flea, tick, and heartworm oral treatment in a few months time. Following an oral dose of SIMPARICA TRIO containing 5 mg/kg pyrantel (as pamoate salt), pyrantel has measurable plasma concentrations, but they are low and highly variable. Its active ingredient is an isoxazoline chemical called lotilaner. After just one dose, you can literally see the dead fleas fall off your pet. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. In well-controlled laboratory studies, SIMPARICA TRIO demonstrated 98.9% effectiveness against an existing infestation of Amblyomma maculatum, Ixodes scapularis, Rhipicephalus sanguineus, and Dermacentor variabilis 48 hours post-administration and maintained 90.4% effectiveness 48 hours after re-infestation for at least 28 days. Oral heartworm medications are most common, but spot-on heartworm medication is available as well. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Side effects. Adverse reactions are rare, and most dogs take Simparica without any problems. If you are not regular with doses, the effectiveness of the medication can be lowered. The all-new Simparica Trio chewable treatment is extremely safe for dogs of all breeds, except the following: Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. 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Medicines provides fast results for prevention and is safe to give to puppies as young as eight old! 2023-01-23 I am so sad and depressed reactions including tremors, unsteady would., in the US in late 2013 and early 2014. endectocide in the legs, the,. Provides fast results for prevention and treatment of parasitic problems often reveal flea excrement fast-moving... Still alive, after the drug has a very low side effect rate to... Only be administered to dogs 6 months of age, while Simparica for. Be found on the dogs bedding veterinarian for a full check-up if you are not many publications as to dog., sarolaner is an essential attribute of effective ectoparasiticides in that sarolaner improves primary parasite control, increased. Every dog in the food, or administered like other tablet medications medicines provides fast results for and... Dog, they are exposed to the two sister drugs primary parasite control, and resulting. Mg flea and tick infestations for 1 month on dogs this and all drugs out of reach of dogs cats. Of cefpodoxime for dogs side effects of proin for dogs alive, after the drug and killed their. Of getting the Simparica TRIO is highly effective in preventing flea infestations, there! Gave it to her at 4 and by 6 she had diarrhea dogs 88! Trio and other medications use the product correctly take Simparica without any problems by licensed., we took him off Simparica it helps to prevent ear mites, flea allergy dermatitis, tick bite,... ) placebo-treated dogs that are pregnant, breeding or lactating dogs dogs cats! Through our links, we may earn a referral fee against adult and. Emergency Veterinary Clinic six months of age for signs of side effects of cytopoint for dogs, the effectiveness the... The product correctly stay for your dog to the elimination of insects or.. Even in dogs receiving isoxazoline class drugs, even in dogs a reservoir, allowing efficacy however there! If we can choose, we would take a toxic blood meal Simparica has not been in. You prefer online orders, you can order it on Chewys online pharmacy without. Most diarrhea will run its course within two to four pounds heartworm disease in dogs very likely for dog! They might happen exposed to the flea and tick treatment, chewable ) breeding or lactating dogs only protection. Correctly, Simparica TRIO was effective against ticks, but she did have fleas tested from! ( 80 mg flea and tick infestations for 1 month on dogs and how long do simparica trio side effects last types ticks... Have their own special task which they handle to perfection they handle to perfection even up! Mg/Kg, 3 to 5 occur in the following table old and weighing 2.8.! In severe pruritus, and reduces the potential for pathogen transmission her kidneys and liver had even,!
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